Alpha-tubulin from early-diverging eukaryotic lineages and the evolution of the tubulin family
نویسندگان
چکیده
منابع مشابه
Six Subgroups and Extensive Recent Duplications Characterize the Evolution of the Eukaryotic Tubulin Protein Family
Tubulins belong to the most abundant proteins in eukaryotes providing the backbone for many cellular substructures like the mitotic and meiotic spindles, the intracellular cytoskeletal network, and the axonemes of cilia and flagella. Homologs have even been reported for archaea and bacteria. However, a taxonomically broad and whole-genome-based analysis of the tubulin protein family has never b...
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15 صفحه اولIntron position conservation across eukaryotic lineages in tubulin genes.
A compilation of intron positions obtained from a large number of eukaryotic genomes across orthologous tubulins is explored for molecular evolution. Comparison of intron positions for 41 alpha, 80 beta, and 30 gamma tubulin genomic sequences indicates that the putative ancestral tubulin gene contained at least 19, 33, and 52 intron positions distributed at different sites in the coding regions...
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T HE tubulin family now includes aand 13-tubulin, which are the main subunits of eukaryotic microtubules; -y-tubulin, which nucleates these microtubules and regulates their dynamics at the minus end (11, 17); and FtsZ, a prokaryotic homolog of the tubulins that is the major cytoskeletal protein in bacterial cell division (5). Two new members, ~and e-tubulin, have been inferred from sequences in...
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When tubulins obtained from particular microtubules of the sea urchin (ciliary doublet A tubules, flagellar doublet microtubules, and mitotic microtubules) are analyzed by electrophoresis in a polyacrylamide gel system containing sodium dodecyl sulfate and urea, heterogeneity of the alpha subunit, and differences between the tubulins are revealed. The alpha subunit of tubulin from mitotic appar...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 1996
ISSN: 0737-4038,1537-1719
DOI: 10.1093/oxfordjournals.molbev.a025576